This is your comprehensive betting guide to week 2 in the NFL as we look over some of the potential lines and totals that you could take advantage of this weekend.. 

We went 2/3 in our betting picks in week 1, as the NFL returned to action in unpredictable fashion. Week 2 gives lines that are a lot easier to jump on with some tight matchups and some low points totals. 

Low spreads generally mean there is opportunity for punters to take advantage of. All matchups for week 2 are below with odds, spreads, lines and titles from 888Sport, as well as our favourite picks of the week.

Week 2 NFL betting lines and odds

Minnesota Vikings at Philadelphia Eagles

Spread: Eagles -7.5

Over/Under Points Total: 48.5

Moneyline: Eagles 3/10 or Vikings 5/2

Kansas City Chiefs at Jacksonville Jaguars

Spread: Chiefs -2.5

Over/Under Points Total: 51.5

Moneyline: Chiefs 13/20 or Jaguars 13/10

Chicago Bears at Tampa Bay Buccaneers

Spread: Buccaneers -3.5

Over/Under Points Total: 41.5

Moneyline: Buccaneers 12/19 or Buccaneers 13/10

Green Bay Packers at Atlanta Falcons

Spread: Packers -1.5

Over/Under Points Total: 40.5

Moneyline: Packers 17/20 or Falcons Evens

Baltimore Ravens at Cincinnati Bengals

Spread: Bengals -3.5

Over/Under Points Total: 46.5

Moneyline: Bengals 4/7 or Ravens 7/5

Los Angeles Chargers at Tennessee Titans

Spread: Chargers -3.5

Over/Under Points Total: 45.5

Moneyline: Chargers 3/5 or Titans 11/8

Las Vegas Raiders at Buffalo Bills

Spread: Bills 9.5

Over/Under Points Total: 46.5

Moneyline: Bills 1/4 or Raiders 16/5

Seattle Seahawks at Detroit Lions

Spread: Lions -5.5

Over/Under Points Total: 47.5

Moneyline: Lions 2/5 or Seahawks 41/20

Indianapolis Colts at Houston Texans

Spread: Colts -1.5

Over/Under Points Total: 39.5

Moneyline: Colts 4/5 or Texans Evens

New York Giants at Arizona Cardinals

Spread: Giants -5.5

Over/Under Points Total: 39.5

Moneyline: Giants 2/5 or Cardinals 47/25

San Francisco 49ers at Los Angeles Rams

Spread: 49ers -7.5

Over/Under Points Total: 44.5

Moneyline: 49ers 29/100 or Rams 11/4

Washington Commanders at Denver Broncos

Spread: Broncos -3.5

Over/Under Points Total: 38.5

Moneyline: Broncos 8/15 or Commanders 29/20

New York Jets at Dallas Cowboys

Spread: Cowboys -9.5

Over/Under Points Total: 39.5

Moneyline: Cowboys 2/9 or Jets 17/5

Miami Dolphins at New England Patriots

Spread: Dolphins -2.5

Over/Under Points Total: 46.5

Moneyline: Dolphins 46/63 or Patriots 23/20

New Orleans Saints at Carolina Panthers

Spread: Saints -3.5

Over/Under Points Total: 39.5

Moneyline: Saints 3/5 or Panthers 11/8

Cleveland Browns at Pittsburgh Steelers

Spread: Browns -2.5

Over/Under Points Total: 40.5

Moneyline: Browns 3/4 or Steelers 11/10

NFL Betting Line Picks

Kansas City Chiefs -2.5 at Jacksonville Jaguars

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The Chiefs are coming off an opening day loss to the Detroit Lions but are favoured on the road against a sound Jaguars team. With Travis Kelce expected to be back, the line is very enticing at -2.5, which basically means the Chiefs need to win by at least a field goal. They stuck around with the Lions despite missing their key target and if Kadarius Toney had caught any of his dropped passes then the Chiefs could have come away with the win. 

Green Bay Packers at Atlanta Falcons - Under 40.5 Total Points

We know what the game plan for the Falcons and head coach Arthur Smith is. Run the damn ball! With two rushing touchdowns and a passing touchdown for rookie running back Bijan Robinson, the Falcons set out what to expect of them in 2023. The Packers ranked 31st in the NFL in run defense in 2022, so the Falcons will fancy their chances even as a moneyline bet. But, the Packers like to run the ball too and this could well be a rushing battle that sees a low points total.

Miami Dolphins -2.5 at New England Patriots

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New Enlgand hung around with the Eagles, limiting their offence much more than anyone expected. Meanwhile the Dolphins offence was humming in their win against the Chargers which saw a magnificent display form Tua and Tyreek Hill. The Dolphins offense should have enough to deal with the Patriots who are a much better defense than the Dolphins face in week 1, but, you have to fancy their chances at only -2.5 favourites.

All Odds From 888Sports

Disclaimer

This article is for information purposes only and is not advice or an advertisement for playing a bet. 

If you are planning on betting on the NFL then please bet responsibly. 

Struggling with gambling? Visit https://www.begambleaware.org/ from the UK or call 1-800-GAMBLER for a 24 hour confidential national hotline.

OWAIN JONES

NFL & NFL DRAFT ANALYST

OWAIN COVERS EVERYTHING NFL & NFL DRAFT. COMING WITH PLENTY OF EXPERIENCE, OWAIN IS ALSO A WRITER FOR PRO FOOTBALL NETWORK AND PREVIOUSLY WAS THE NFL DRAFT EDITOR AT NINETY-NINE YARDS WHERE HE CREATED DRAFT TALK, A NFL DRAFT PODCAST FOR NINETY-NINE YARDS. YOU CAN FOLLOW HIM ON TWITTER @OWAIN_JONES_

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